ChemicalBook > CAS DataBase List > LY 2606368

LY 2606368

Product Name
LY 2606368
CAS No.
1234015-52-1
Chemical Name
LY 2606368
Synonyms
CS-1453;LY 2606368;Prexasertib;Prexasertib free base;Prexasertib (LY2606368);LY 2606368;LY-2606368;PREXASERTIB;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile;5-[[5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile LY2606368
CBNumber
CB82667926
Molecular Formula
C18H19N7O2
Formula Weight
365.39
MOL File
1234015-52-1.mol
More
Less

LY 2606368 Property

Boiling point:
608.5±55.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in DMSO
form 
A crystalline solid
pka
11.89±0.10(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
21490
Product name
LY2606368
Purity
≥98%
Packaging
1mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
21490
Product name
LY2606368
Purity
≥98%
Packaging
5mg
Price
$486
Updated
2024/03/01
Cayman Chemical
Product number
21490
Product name
LY2606368
Purity
≥98%
Packaging
10mg
Price
$799
Updated
2024/03/01
Cayman Chemical
Product number
21490
Product name
LY2606368
Purity
≥98%
Packaging
25mg
Price
$1141
Updated
2024/03/01
Usbiological
Product number
454002
Product name
LY 2606368
Packaging
500ug
Price
$566
Updated
2021/12/16
More
Less

LY 2606368 Chemical Properties,Usage,Production

Description

LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of <13 nM in a viability study of multiple colorectal cancer cell lines. Inhibition of Chk1 causes double-strand DNA breakage in cells leading to an excessive cell damage burden and subsequent cell death. In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.

Uses

LY 2606368 is a novel CHK1 inhibitor under investigation as a chemopotentiating agent. It causes double-stranded DNA breakage while simultaneously removing the protection of the DNA damage checkpoints. LY 2606368 is representative of a novel class of drugs for the treatment of cancer and tumor growth inhibition.

References

[1] wu w, bi c, bence a k, et al. antitumor activity of chk1 inhibitor ly2606368 as a single agent in sw1990 human pancreas orthotopic tumor model. cancer research, 2012, 72(8 supplement): 1776.
[2] lainchbury m, matthews t p, mchardy t, et al. discovery of 3-alkoxyamino-5-(pyridin-2-ylamino) pyrazine-2-carbonitriles as selective, orally bioavailable chk1 inhibitors. journal of medicinal chemistry, 2012, 55(22): 10229-10240.
[3] mcneely s c, burke t f, durlandbusbice s, et al. abstract a108: ly2606368, a second generation chk1 inhibitor, inhibits growth of ovarian carcinoma xenografts either as monotherapy or in combination with standard-of-care agents. molecular cancer therapeutics, 2011, 10(supplement 1): a108.

LY 2606368 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

LY 2606368 Suppliers

China 77 United States 10 Global 87
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9926
Advantage
65
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

1234015-52-1, LY 2606368Related Search:

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY-404039 LY3143921 LY 379268 LY-2940094 LY2109761 LY 294002 HYDROCHLORIDE LY 2784544

  • LY 2606368
  • 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile LY2606368
  • 5-[[5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile
  • 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile
  • Prexasertib
  • LY 2606368;LY-2606368;PREXASERTIB
  • Prexasertib (LY2606368)
  • CS-1453
  • 2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-
  • Prexasertib free base
  • SIK,Prexasertib,LY 2606368,Checkpoint Kinase (Chk),HT-29,S296,Apoptosis,DNA,double-stranded,inhibit,autophosphorylation,H2AX,ATP-competitive,HeLa,MELK,RSK1,CDK2,LY-2606368,Inhibitor,S516,ARK5,replication,BRSK2,CDC25A
  • 1234015-52-1
  • C18H19N7O2